Azapeptides with unique covalent warheads as SARS-CoV-2 main protease inhibitors
Kaustav Khatua, Yugendar R. Alugubelli, Kai S. Yang, Veerabhadra R. Vulupala, Lauren R. Blankenship, Demonta Coleman, Sandeep Atla, Sankar P. Chaki, Zhi Geng, R. Xinyu, Jing Xiao, Peng-Hsun Chen, Chia-Chuan D. Cho, Shivangi Sharma, Erol C. Vatansever, Yuying Ma, Ge Yu, Benjamin W. Neuman, Shiqing Xu, Wenshe Ray Liu
Topics & Concepts
ProteasePapainProteasesCysteineCysteine proteaseChemistryWarheadCysteine Proteinase InhibitorsBiochemistryOxyanion holeEnzymeCovalent bondActive siteApoptosisCaspaseAerospace engineeringEngineeringOrganic chemistryProgrammed cell deathClick Chemistry and ApplicationsSARS-CoV-2 and COVID-19 ResearchAntimicrobial Peptides and Activities