Exploring the SARS-CoV-2 structural proteins for multi-epitope vaccine development: an <i>in-silico</i> approach
Amit Kumar, Prateek Kumar, Kumar Udit Saumya, Shivani Krishna Kapuganti, Taniya Bhardwaj, Rajanish Giri
Abstract
INTRODUCTION: The ongoing life-threatening pandemic of coronavirus disease 2019 (COVID-19) has extensively affected the world. During this global health crisis, it is fundamentally crucial to find strategies to combat SARS-CoV-2. Despite several efforts in this direction and continuing clinical trials, no vaccine has been approved for it yet. METHODS: To find a preventive measure, we have computationally designed a multi-epitopic subunit vaccine using immuno-informatic approaches. RESULTS: . CONCLUSION: to check its potency in a cure for COVID-19.
Topics & Concepts
EpitopeImmunogenicityIn silicoComputational biologyAntigenVirologyImmune systemBiologyEpitope mappingPandemicVaccine efficacySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)ImmunologyDiseaseMedicineInfectious disease (medical specialty)GeneticsGenePathologyvaccines and immunoinformatics approachesImmunotherapy and Immune ResponsesInfluenza Virus Research Studies