A metal-free BF<sub>3</sub>·OEt<sub>2</sub> mediated chemoselective protocol for the synthesis of propargylic cyclic imines
Prasoon Raj Singh, Braj Gopal, Madan Kumar, Avijit Goswami
Abstract
has been established. The newly developed methodology provided access to a variety of propargylic cyclic imines in good to excellent yields. In addition, the synthesis of propargylic amines and the corresponding very stable enol derivatives from the title compound is also explored.
Topics & Concepts
ChemistryImineCombinatorial chemistryCycloadditionEnolMetalStereochemistryMedicinal chemistryOrganic chemistryCatalysisCyclopropane Reaction MechanismsCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods