Sterically controlled C–H alkenylation of pyrroles and thiophenes
Eunsu Kang, Ju Eun Jeon, Siyeon Jeong, Hyun Tae Kim, Jung Min Joo
Abstract
-alkyl pyrroles and 3-substituted thiophenes, as opposed to electronically controlled approaches, are developed. The steric demand and stable bidentate binding mode of the pyrazolonaphthyridine ligand are key to the success of these sterically controlled alkenylations using oxygen as an oxidant.
Topics & Concepts
Steric effectsChemistryDenticityAlkylLigand (biochemistry)Combinatorial chemistryStereochemistryOrganic chemistryReceptorBiochemistryMetalCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis and Characterization of Pyrroles