Antibody–Drug Conjugates: Advancing from Magic Bullet to Biological Missile
Ana Veneziani, Suku Sneha, Amit M. Oza
Abstract
Precision drug development is focusing on targeting tumor cell surface proteins for therapeutic delivery, maximizing biomarker identified on-target damage to the tumor while minimizing toxicity. A recent article demonstrated high expression of B7-H4 antigen on resistant ovarian cancer cells and described preclinical activity of B7-H4-directed antibody-drug conjugate. See related article by Gitto et al., p. 1567.
Topics & Concepts
Magic bulletDrugConjugateMissileMedicineAntibody-drug conjugateVirologyAntibodyPharmacologyImmunologyBiologyEngineeringMonoclonal antibodyBioinformaticsAerospace engineeringMathematicsMathematical analysisHER2/EGFR in Cancer ResearchMonoclonal and Polyclonal Antibodies ResearchRadiopharmaceutical Chemistry and Applications