Pharmacological activation of aldehyde dehydrogenase 2 inhibits ferroptosis via SLC7A11/GPX4 axis to reduce kidney stone formation
Jingdong Zhang, Rui Wang, Linguo Xie, Haotian Ren, Di Luo, Yang Yu, Haijie Xie, Zhiqun Shang, Chunyu Liu
Abstract
levels. These collective effects attenuated crystal-induced ferroptosis. However, the renoprotective effects of Alda-1 were inhibited by SLC7A11 siRNA. In conclusion, our study explores the applications of Alda-1 and highlights the potential of targeting ALDH2 as a promising therapeutical strategy for urolithiasis.
Topics & Concepts
Aldehyde dehydrogenaseKidneyChemistryAldehydeCell biologyBiochemistryEnzymeMedicineBiologyInternal medicineCatalysisFerroptosis and cancer prognosisCaveolin-1 and cellular processesIon Transport and Channel Regulation