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Pharmacokinetic tuning of protein–antigen fusions enhances the immunogenicity of T-cell vaccines

Naveen K. Mehta, Roma Pradhan, Ava P. Soleimany, Kelly D. Moynihan, Adrienne M. Rothschilds, Noor Momin, Kavya Rakhra, Jordi Mata-Fink, Sangeeta N. Bhatia, K. Dane Wittrup, Darrell J. Irvine

2020Nature Biomedical Engineering66 citationsDOIOpen Access PDF

Topics & Concepts

ImmunogenicityEpitopeAntigenPeptideVirologyFusion proteinImmune systemProtein subunitBiologyImmunologyRecombinant DNABiochemistryGeneImmunotherapy and Immune ResponsesMonoclonal and Polyclonal Antibodies Researchvaccines and immunoinformatics approaches
Pharmacokinetic tuning of protein–antigen fusions enhances the immunogenicity of T-cell vaccines | Litcius