Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome <i>bd</i> and Chemical Validation of Combination Strategies for Respiratory Inhibitors against <i>Mycobacterium tuberculosis</i>
Laura N. Jeffreys, Alison Ardrey, Taghreed A. Hafiz, Lauri-Anne Dyer, Ashley J. Warman, Nada Mosallam, Gemma L. Nixon, Nicholas Fisher, W. David Hong, Suet C. Leung, Ghaith Aljayyoussi, Jaclyn Bibby, Deepak V. Almeida, Paul J. Converse, Nader Fotouhi, Neil G. Berry, Eric L. Nuermberger, Anna M. Upton, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Abstract
as a combination strategy to improve therapeutic and pharmacokinetic/pharmacodynamic (PK/PD) indices related to efficacy.
Topics & Concepts
Mycobacterium tuberculosisPharmacologyPharmacophoreIn vivoRespiratory chainBiologyBiochemistryChemistryTuberculosisEnzymeMedicinePathologyBiotechnologyTuberculosis Research and EpidemiologyCancer therapeutics and mechanismsBiochemical and Molecular Research