Dipeptidyl peptidase 4 inhibition rescues PKA-eNOS signaling and suppresses aortic hypercontractility in male rats with heart failure
Milene Tavares Fontes, Daniel F. Arruda-Junior, Danúbia Silva dos Santos, João Carlos Ribeiro-Silva, Edinei L. Antônio, Paulo Ferreira Tucci, Luciana Venturini Rossoni, Adriana C. C. Girardi
Topics & Concepts
EnosInternal medicinePhenylephrineNADPH oxidaseDipeptidyl peptidase-4EndocrinologyVildagliptinMedicineVasoprotectiveNitric oxideMesenteric arteriesDipeptidyl peptidase-4 inhibitorEndothelial dysfunctionHeart failureTelmisartanNitric oxide synthaseOxidative stressArteryDiabetes mellitusBlood pressureType 2 Diabetes MellitusType 2 diabetesPeptidase Inhibition and AnalysisDiabetes Treatment and ManagementCardiovascular Function and Risk Factors