Trained Innate Immunity Induced by Vaccination with Low-Virulence <i>Candida</i> Species Mediates Protection against Several Forms of Fungal Sepsis via Ly6G <sup>+</sup> Gr-1 <sup>+</sup> Leukocytes
Elizabeth A. Lilly, Breah E. Bender, Shannon K. Esher, Paul L. Fidel, Mairi C. Noverr
Abstract
Trained innate immunity (TII) is induced following immunization with live attenuated microbes and represents a clinically important strategy to enhance innate defenses. TII was initially demonstrated following intravenous inoculation with low-virulence Candida albicans , with protection against a subsequent lethal C. albicans intravenous bloodstream infection (BSI) mediated by monocytes with enhanced cytokine responses.
Topics & Concepts
Innate immune systemVirulenceImmunityVaccinationMicrobiologySepsisBiologyImmunologyVirologyImmune systemGeneGeneticsImmune responses and vaccinationsImmunodeficiency and Autoimmune DisordersZoonotic diseases and public health