Sodium thiosulfate prevents doxorubicin-induced DNA damage and apoptosis in cardiomyocytes in mice
Yukie Mizuta, Kentaro Tokuda, Jie Guo, Shuo Zhang, Sayoko Narahara, Takahito Kawano, Masaharu Murata, Ken Yamaura, Sumio Hoka, Makoto Hashizume, Tomohiko Akahoshi
Topics & Concepts
DoxorubicinSuperoxide dismutasePharmacologyApoptosisCardiotoxicityOxidative stressCatalaseChemistryLactate dehydrogenaseDNA damageReactive oxygen speciesAntioxidantSodium thiosulfateDNA fragmentationCreatine kinaseBiochemistryInternal medicineMedicineEnzymeToxicityChemotherapyDNAProgrammed cell deathInorganic chemistryChemotherapy-induced cardiotoxicity and mitigationCardiac Ischemia and ReperfusionChemotherapy-induced organ toxicity mitigation