A pharmacokinetic and biomarker study of delayed-release dimethyl fumarate in subjects with secondary progressive multiple sclerosis: evaluation of cerebrospinal fluid penetration and the effects on exploratory biomarkers
Keith R. Edwards, Aneesh Kamath, Judy Button, Vineetha Kamath, Jason P. Mendoza, Bing Zhu, Tatiana Plavina, Caroline Woodward, Natalia A. Penner
Topics & Concepts
Dimethyl fumarateCerebrospinal fluidMultiple sclerosisMedicineBiomarkerGlial fibrillary acidic proteinNeuroprotectionPharmacokineticsPharmacologyInternal medicinePathologyGastroenterologyImmunologyChemistryBiochemistryImmunohistochemistryMultiple Sclerosis Research StudiesAmyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms