Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19
Teodor‐D. Brumeanu, Pooja Vir, Ahmad Faisal Karim, Swagata Kar, Dalia Benetiene, Megan Lok, Jack Greenhouse, Tammy Putmon-Taylor, Christopher Kitajewski, Kevin K. Chung, Kathleen P. Pratt, Sofía Casares
Abstract
human model for studying SARS-CoV-2 immunopathological mechanisms and testing the safety and efficacy of candidate vaccines and therapeutics.
Topics & Concepts
Humanized mouseImmunologyImmune systemBiologyCD8GranzymeHuman cytomegalovirusVirologyPerforinVirusSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCOVID-19 Impact on Reproduction