Suppression of stemness and enhancement of chemosensibility in the resistant melanoma were induced by Astragalus polysaccharide through PD-L1 downregulation
Qianyi Gong, Hua Yu, Guiqing Ding, Jinyun Ma, Yuanhua Wang, Xiaodong Cheng
Topics & Concepts
Downregulation and upregulationMelanomaCancer researchAstragalusPI3K/AKT/mTOR pathwayTumor microenvironmentCisplatinBiologyProtein kinase BChemotherapyMedicineSignal transductionGeneCell biologyTraditional Chinese medicinePathologyBiochemistryTumor cellsGeneticsAlternative medicineCancer Immunotherapy and BiomarkersMelanoma and MAPK PathwaysCancer Cells and Metastasis