The bronchoalveolar lavage dilution conundrum: an updated view on a long-standing problem
Sarah M. Haeger, Camille M. Moore, Shannon A. McManus, Peter K. Moore, William J. Janssen, Kara J. Mould
2024American Journal of Physiology-Lung Cellular and Molecular Physiology12 citationsDOIOpen Access PDF
Abstract
In this report, mathematical prediction models and real-world measurements are used to compare the performance of molecular markers of dilution in bronchoalveolar lavage fluid samples. Effects of acute inflammation within individual subjects are highlighted. These findings inform recommendations for normalizing measurements across bronchoalveolar lavage samples and highlight the need for additional markers to improve the rigor of translational studies utilizing bronchoalveolar lavage measurements.
Topics & Concepts
Bronchoalveolar lavageMedicineDilutionInflammationPathologyLungAlbuminImmunologyInternal medicinePhysicsThermodynamicsAsthma and respiratory diseasesNeonatal Respiratory Health ResearchChronic Obstructive Pulmonary Disease (COPD) Research