Sequential Release of Small Extracellular Vesicles from Bilayered Thiolated Alginate/Polyethylene Glycol Diacrylate Hydrogels for Scarless Wound Healing
Yifan Shen, Guanzhe Xu, Huanxuan Huang, Kaiyang Wang, Hui Wang, Meidong Lang, Hong Gao, Shichang Zhao
Abstract
model, tissues in the groups treated with BSSPD loaded with sEVs for sequential release (SR-sEVs@BSSPD) exhibited a more uniform vascular structure distribution, more regular collagen arrangement, and lower volume of hyperplastic scar tissue than tissues in the other groups. Hence, SR-sEVs@BSSPD based on skin repair phases was successfully designed and has considerable potential as a cell-free therapy for scarless wound healing.
Topics & Concepts
Self-healing hydrogelsWound healingAngiogenesisMesenchymal stem cellBiomedical engineeringMaterials scienceFibroblastSkin repairBone healingCell biologyChemistryBiophysicsCancer researchMedicineSurgeryIn vitroBiochemistryBiologyPolymer chemistryWound Healing and TreatmentsExtracellular vesicles in diseaseTendon Structure and Treatment