<scp>IL</scp>‐1α/β and <scp>IL</scp>‐18 profiles and their impact on claudin‐1, loricrin and filaggrin expression in patients with atopic dermatitis
M. Michaelidou, Davender Redhu, V. Visha Kumari, Magda Babina, Margitta Worm
Abstract
F I G U R E 2Interference with the nuclear factor kappa B (NF-B) pathway using an IkB kinase inhibitor (IKKI) peptide partially restores the decreased expression of loricrin and profilaggrin, but not claudin-1 in the presence of IL-1/ and IL-18.mRNA levels of (a) claudin-1 (b) loricrin and (c) pro-filaggrin in human skin explants (hSEs) in the presence of IL-1/ and IL-18 (n = 8).mRNA levels of (d) claudin-1 (e) loricrin and (f) profilaggrin in hSEs in the presence of IL-1 and IL-18 with or without IKKI (n = 4).Dot plots are represented with mean SEM (*p < 0.05, **p < 0.01).
Topics & Concepts
Atopic dermatitisMedicineAllergyFood allergyFilaggrinDermatologyImmunologyDermatology and Skin DiseasesInflammasome and immune disordersAsthma and respiratory diseases