RamAp Is an Efflux Pump Regulator Carried by an IncHI2 Plasmid
Yu-Ping Hong, You-Wun Wang, Bo-Han Chen, Hui-Yung Song, Chien-Shun Chiou, Ying-Tsong Chen
Abstract
is an extra efflux pump activator gene that potentially could be transmitted with the IncHI2 plasmid among bacteria. It is plausible that, with high interspecific conservation, the plasmid-encoded regulator reduces drug susceptibility by activating existing efflux pump systems of the host and thus can be regarded as a new type of auxiliary antimicrobial resistance determinant. Sequences of similar plasmids were found worldwide. Its impact on the emergence of antimicrobial resistance among bacterial pathogens is worrisome.
Topics & Concepts
EffluxPlasmidSalmonella entericaBiologyEscherichia coliGeneMicrobiologyEnterobacteriaceaeMultiple drug resistanceGeneticsRegulatorAntibacterial agentAntibiotic resistanceInsertion sequenceKlebsiella pneumoniaeNalidixic acidGene cassetteDrug resistanceResistomeTetRRegulator geneSalmonellaMolecular biologyKlebsiella oxytocaAntimicrobialRepliconTetracyclineEscherichia coli research studiesBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria