Pgam5-mediated PHB2 dephosphorylation contributes to endotoxemia-induced myocardial dysfunction by inhibiting mitophagy and the mitochondrial unfolded protein response
Chen Cai, Ziying Li, Zemao Zheng, Zhongzhou Guo, Qian Li, Shuxian Deng, Nengxian Shi, Qing Ou, Hao Zhou, Zhigang Guo, Zhongqing Chen, Hang Zhu
Abstract
are potential targets for the treatment of endotoxemia-related cardiac dysfunction.
Topics & Concepts
MitophagyMitochondrionCell biologyMitochondrial ROSBiologyChemistryAutophagyApoptosisBiochemistryMitochondrial Function and PathologyAutophagy in Disease and TherapyCancer, Hypoxia, and Metabolism