A textile-reinforced composite vascular graft that modulates macrophage polarization and enhances endothelial cell migration, adhesion and proliferation <i>in vitro</i>
Fan Zhang, Hui Tao, Jessica M. Gluck, Lu Wang, Mani A. Daneshmand, Martin W. King
Abstract
. The composite vascular graft also enhances macrophage activation and upregulates M1 and M2 related gene expression, which further improves the endothelial cell migration that might favor the reendothelialization of the vascular graft. Taken together, the textile-reinforced hydrogel shows it potential to be a promising scaffold material to fabricate a tissue engineered vascular graft.
Topics & Concepts
AdhesionMacrophage polarizationMaterials scienceIn vitroScaffoldCell biologyComposite numberEndothelial stem cellBiomedical engineeringMacrophageChemistryMedicineComposite materialBiologyBiochemistryElectrospun Nanofibers in Biomedical Applications3D Printing in Biomedical ResearchGraphene and Nanomaterials Applications