Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy
Zhiyong Liu, Meng‐Si Wu, Yudong Xue, Chao Chen, Frederik R. Wurm, Minbo Lan, Weian Zhang
Abstract
An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.
Topics & Concepts
PhotosensitizerPhotodynamic therapyChlorinConjugated systemChemistryNano-PhotochemistryMaterials scienceOrganic chemistryPolymerComposite materialNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Nanomaterials in Catalysis