Generating 3D human cardiac constructs from pluripotent stem cells
Chang Liu, Xing Feng, Guoping Li, Priyanka Gokulnath, Junjie Xiao
Abstract
Human pluripotent stem cell (hPSC) technology has offered nearly infinite opportunities to model all kinds of human diseases in vitro. Cardiomyocytes derived from hPSCs have proved to be efficient tools for cardiac disease modeling, drug screening and pathological mechanism studies. In this review, we discuss the advantages and limitations of 2D hPSC-cardiomyocyte (hPSC-CM) system, and introduce the recent development of three-dimensional (3D) culture platforms derived from hPSCs. Although the development of bioengineering technologies has greatly improved 3D platform construction, there are certainly challenges and room for development for further in-depth research.
Topics & Concepts
Induced pluripotent stem cellStem cellBiologyComputational biologyCell biologyMedicineEmbryonic stem cellGeneticsGenePluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine3D Printing in Biomedical Research