E‐cadherin deregulation in breast cancer
Giovanni Corso, Joana Figueiredo, Simone Pietro De Angelis, Federica Corso, Antonia Girardi, Joana Pereira, Raquel Seruca, Bernardo Bonanni, Patrı́cia Carneiro, Gabriella Pravettoni, Elena Guerini‐Rocco, Paolo Veronesi, Giacomo Montagna, Virgilio Sacchini, Sara Gandini
Abstract
E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
Topics & Concepts
CDH1CadherinBreast cancerCancer researchCancerBiomarkerMedicineGeneOncologyInternal medicineBiologyBioinformaticsGeneticsCellWnt/β-catenin signaling in development and cancerCancer-related gene regulationCancer Cells and Metastasis