VEGF-attenuated platelet-rich plasma improves therapeutic effect on cartilage repair
Jae Sung Lee, Ping Guo, Katarina Klett, MacGregor N. Hall, Krishna Murari Sinha, Sudheer Ravuri, Johnny Huard, William L. Murphy
Abstract
. In addition, healing of rat OA cartilage was significantly improved after treatment with VEGF-attenuated PRP when compared to the PRP treatment group or PBS control group. We expect that attenuation of unwanted biological activity using growth factor-binding microspheres could provide a new PRP customization method broadly applicable to various tissue repair processes.
Topics & Concepts
Platelet-rich plasmaCartilageAngiogenesisChondrogenesisOsteoarthritisMedicineVascular endothelial growth factorChemistryIn vitroCancer researchPharmacologyVEGF receptorsImmunologyPlateletPathologyAnatomyBiochemistryAlternative medicinePeriodontal Regeneration and TreatmentsKnee injuries and reconstruction techniquesTendon Structure and Treatment