<i>FN1</i> mRNA 3'-UTR supersedes traditional fibronectin 1 in facilitating the invasion and metastasis of gastric cancer through the <i>FN1</i> 3'-UTR-let-7i-5p-THBS1 axis
Siwei Pan, Jiaming Zhu, Pengfei Liu, Qiaochu Wei, Siyu Zhang, Wen An, Yuxin Tong, Zhenguo Cheng, Funan Liu
Abstract
3'-UTR may be a better therapeutic target for constructing targeted drugs in GC than the FN1 protein.
Topics & Concepts
Untranslated regionThree prime untranslated regionMessenger RNADownregulation and upregulationBiologyCancer researchMetastasisCancerIn vivoMolecular biologyGeneGeneticsRNA modifications and cancerRNA Research and SplicingCancer-related molecular mechanisms research