Folate-modified triptolide liposomes target activated macrophages for safe rheumatoid arthritis therapy
Ruibo Guo, Xinyue Zhang, De-kang Yan, Yingjie Yu, Yujia Wang, Hong-xia Geng, Yanan Wu, Yang Liu, Liang Kong, Xuetao Li
Abstract
experiments revealed that liposomes could prolong the circulation of TP in the body, as well as exhibit significant cartilage-protective and anti-inflammatory effects with lower toxicity compared with the free TP group, thereby providing a promising new approach for the treatment of RA.
Topics & Concepts
TriptolideRheumatoid arthritisChemistryArthritisCartilageLiposomeInflammationIn vivoPharmacologyCytotoxicityIn vitroSynovial membraneImmunologyMedicineBiochemistryApoptosisBiologyBiotechnologyAnatomyNatural Compounds in Disease TreatmentAutoimmune and Inflammatory Disorders ResearchRheumatoid Arthritis Research and Therapies