Penisarins A and B, Sesquiterpene Coumarins Isolated from an Endophytic <i>Penicillium</i> sp.
Wei Li, Ya-Ting Shao, Tianpeng Yin, Hui Yan, Baochun Shen, Yuan-Yi Li, Huiding Xie, Zhongwen Sun, Yu‐Lu Ma
Abstract
Penisarins A (1) and B (2), sesquiterpene coumarins with an unusual tricyclic sesquiterpene system, were isolated from endophytic Penicillium sp. KMU18029. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compound 2 showed significant cytotoxicities against two human cancer cell lines, HL-60 and SMMC-7721, with IC50 values of 3.6 ± 0.2 and 3.7 ± 0.2 μM, respectively.
Topics & Concepts
SesquiterpeneCircular dichroismStereochemistryPenicilliumChemistryAsteraceaeCancer cell linesPlant use of endophytic fungi in defenseBotanyBiologyCancer cellCancerFood scienceGeneticsMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsPlant chemical constituents analysis