Structural modification may be a way to make isoquinoline alkaloids efficient antibacterial drugs
Hui Wang, Yuanjing Zhao, Haoran Xu, Ping Wang, Simin Chen
Abstract
Isoquinoline alkaloids are a kind of small molecular compounds with isoquinoline structure which widely exist in natural plants. A large number of studies have confirmed that these substances have a variety of biological activities, such as antibacterial, anti-tumor, anti-hyperglycemia, anti-virus, anti-inflammation, regulation of metabolism and so on. However, the low solubility and over-mild action of these substances limit their application. Based on the pharmacodynamic characteristics, application prospect and clinical demand of isoquinoline alkaloids, we aim to review the antibacterial activity of isoquinoline alkaloids and find new modification sites and groups of isoquinoline alkaloids. to provide reference for the structural design of new drug molecules and fully explore its potential clinical application value.