Estrogen receptor α controls metabolism in white and brown adipocytes by regulating <i>Polg1</i> and mitochondrial remodeling
Zhenqi Zhou, Timothy M. Moore, Brian G. Drew, Vicent Ribas, Jonathan Wanagat, Mete Civelek, Mayuko Segawa, Dane M. Wolf, Frode Norheim, Marcus Seldin, Alexander R. Strumwasser, Kate Whitney, Ellen Lester, Britany R. Reddish, Laurent Vergnes, Karen Reue, Prashant Rajbhandari, Peter Tontonoz, Jason T. Lee, Sushil K. Mahata, Sylvia C. Hewitt, Orian S. Shirihai, Craig Gastonbury, Kerrin S. Small, Markku Laakso, Jørgen Jensen, Sindre Lee-Ødegård, Christian A. Drevon, Kenneth S. Korach, Aldons J. Lusis, Andrea L. Hevener
Abstract
promoter to control its expression in 3T3L1 adipocytes. These findings support strategies leveraging ERα action on mitochondrial function in adipocytes to combat obesity and metabolic dysfunction.
Topics & Concepts
Estrogen receptorBiologyAdipocyteEstrogenGeneGene expressionReceptorLipid metabolismEndocrinologyFunction (biology)Internal medicineGeneticsMedicineAdipose tissueCancerBreast cancerAdipose Tissue and MetabolismMitochondrial Function and PathologyAdipokines, Inflammation, and Metabolic Diseases