Potency of Olorofim (F901318) Compared to Contemporary Antifungal Agents against Clinical Aspergillus fumigatus Isolates and Review of Azole Resistance Phenotype and Genotype Epidemiology in China
Huilin Su, Min Zhu, Clement K. M. Tsui, Henrich van der Lee, Marlou Tehupeiory-Kooreman, Jan Zoll, Tobias Engel, Li Li, Junhao Zhu, Zihan Lu, Qiangqiang Zhang, Paul E. Verweij, Shuwen Deng
Abstract
/L98H/S297T/F495I mutations among TRAF isolates might have evolved from separate local isolates in China. Continuous isolation of TRAF in China underscores the need for systematic resistance surveillance as well as the need for novel drug targets such as olorofim.
Topics & Concepts
Aspergillus fumigatusAzoleAspergillosisBiologyPotencyAspergillusGenotypeAntifungalMicrobiologyDrug resistanceImmunologyGeneIn vitroGeneticsAntifungal resistance and susceptibilityFungal Infections and StudiesFungal Plant Pathogen Control