Extracellular matrix proteins refine microenvironments for pancreatic organogenesis from induced pluripotent stem cell differentiation
Ming Hu, Tianzheng Liu, Hui Huang, Derek A. Ogi, Yinfei Tan, Kaiming Ye, Sha Jin
Abstract
We demonstrated dpECM's crucial role in refining stem cell differentiation microenvironments for organoid development and maturation. Our findings on biomaterial-stimulated signaling for stem cell specification, organogenesis, and maturation open up a new way to increase the differentiation efficacy of endocrine tissues that can contribute to the production of biologically functional islets.
Topics & Concepts
OrganogenesisExtracellular matrixCell biologyInduced pluripotent stem cellStem cellCellular differentiationExtracellularBiologyChemistryMatrix (chemical analysis)BiochemistryEmbryonic stem cellChromatographyGenePancreatic function and diabetes