Multifunctional organometallic compounds for the treatment of Chagas disease: Re(<scp>i</scp>) tricarbonyl compounds with two different bioactive ligands
Mariano Soba, Gonzalo Scalese, Federico Casuriaga, Nicolás Pérez, Nicolás Veiga, Gustavo A. Echeverría, Oscar E. Piro, Ricardo Faccio, Leticia Pérez‐Díaz, Gilles Gasser, Ignacio Machado, Dinorah Gambino
Abstract
a similar mode of action as that disclosed for the single bioactive moieties included in the new chemical entities. Additionally, two relevant physicochemical properties of biological interest in prospective drug development, namely lipophilicity and stability in solution in different media, were determined. The whole set of results demonstrates the potentiality of these Re(I) tricarbonyls as promising candidates for further antitrypanosomal drug development.
Topics & Concepts
Trypanosoma cruziChagas diseaseLipophilicityLanosterolVero cellAntiprotozoalChemistryDrugMechanism of actionCombinatorial chemistryPharmacologyIn vitroStereochemistryBiochemistryBiologyParasite hostingImmunologySterolCholesterolWorld Wide WebComputer scienceSynthesis and Biological EvaluationMetal complexes synthesis and propertiesMacrophage Migration Inhibitory Factor