Discovery and SAR analysis of 5-chloro-4-((substituted phenyl)amino)pyrimidine bearing histone deacetylase inhibitors
Lin Zhang, Yiming Chen, Fahui Li, Lihui Zhang, Jinhong Feng, Lei Zhang
Abstract
promoted G0/G1 phase cell cycle arrest and apoptosis of K562 cells.
Topics & Concepts
ChemistryHDAC8SelectivityIC50Histone deacetylaseHDAC1HDAC6Structure–activity relationshipPotencyBiochemistryStereochemistryHistoneIn vitroGeneCatalysisHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsClick Chemistry and Applications