Electrochemical selective divergent C–H chalcogenocyanation of <i>N</i>-heterocyclic scaffolds
Kusum Ucheniya, Pooja Kumari Jat, Amreen Chouhan, Lalit Yadav, Satpal Singh Badsara
Abstract
]quinolines were also successfully chalcogenocyanated under the optimized reaction conditions providing a platform for the synthesis of pharmaceutically privileged molecules. By switching the reaction conditions, the developed protocol offers selective synthesis of C-3 thiocyanate and 1,3 bis-thiocyanate indolizines in good to excellent yields under catalyst-free conditions. On the basis of control experiments and cyclic voltammetry data, a plausible reaction pathway is also presented.
Topics & Concepts
IndolizineChromoneElectrochemistryChemistryEnonePolar effectCombinatorial chemistryMedicinal chemistryStereochemistryElectrodePhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis and Reactivity of Heterocycles