Research progress on rheumatoid arthritis-associated depression
Nian Liu, Weitian Yan, Rong Su, Lin Zhang, Xingqiang Wang, Zhaofu Li, Dongdong Qin, Jiangyun Peng
Abstract
Depression is an independent mood disorder and one of the most common comorbidities of rheumatoid arthritis (RA). Growing evidence suggests that there is two-way regulation between RA and depression, resulting in a vicious cycle of RA, depression, poor outcomes, and disease burden. The rising prevalence of RA-associated depression warrants a re-examination of the relationships between them. Here we provide an overview of the etiology and pathological mechanisms of RA-associated depression, and recent advances in treatment with biologics, which will facilitate the development of new and effective prevention and treatment strategies.
Topics & Concepts
Rheumatoid arthritisDepression (economics)EtiologyMedicineMoodPathologicalDiseaseMood disordersArthritisPsychiatryIntensive care medicineInternal medicineAnxietyEconomicsMacroeconomicsTryptophan and brain disordersMultiple Sclerosis Research StudiesRheumatoid Arthritis Research and Therapies