Stereoselective Electro‐2‐deoxyglycosylation from Glycals
Miao Liu, Kaimeng Liu, De‐Cai Xiong, Hanyu Zhang, Tian Li, Bohan Li, Xianjin Qin, Jinhe Bai, Xin‐Shan Ye
Abstract
Abstract We report a novel and highly stereoselective electro‐2‐deoxyglycosylation from glycals. This method features excellent stereoselectivity, scope, and functional‐group tolerance. This process can also be applied to the modification of a wide range of natural products and drugs. Furthermore, a scalable synthesis of glycosylated podophyllotoxin and a one‐pot trisaccharide synthesis through iterative electroglycosylations were achieved.
Topics & Concepts
StereoselectivityChemistryTrisaccharidePodophyllotoxinCombinatorial chemistryGlycosylationStereochemistryOrganic chemistryCatalysisBiochemistryCarbohydrate Chemistry and SynthesisSynthetic Organic Chemistry MethodsTraditional and Medicinal Uses of Annonaceae