Litcius/Paper detail

CO <sub>2</sub> upgrading into bioproducts using a two-step abiotic–biotic system

Geonhui Lee, Gea‐Jae Joo, Ji-Hoon Choi, Maria Fonseca Guzman, Yu Shan, Han K. D. Le, Julian Feijóo, Nathan E. Soland, Douglas S. Clark, Peidong Yang

2025Proceedings of the National Academy of Sciences16 citationsDOIOpen Access PDF

Abstract

The valorization of CO 2 to chemicals beyond C 1-2 products is receiving significant interest; however, the direct electrosynthesis of C n molecules (n &gt; 4) remains a challenge. Here, we present a two-step abiotic–biotic system for upgrading CO 2 into the biopolymer, poly(3-hydroxybutyrate). In the electrolysis system, CO 2 is converted into C 2 oxygenates using a Cu–Ag tandem electrocatalyst. The electrolysis process generates a liquid stream containing ~ 200 mM acetate in a bio-compatible electrolyte. This electrosynthesized acetate is then fed to a bioreactor, where the substrate is upgraded by Cupriavidus necator to biopolymer with a maximum rate of 32 ± 3.5 mg L −1 h −1 . We further demonstrate the purification of the resulting biopolymer into a powder. The high productivity of the abiotic–biotic system demonstrates its feasibility for sustainable chemical manufacturing.

Topics & Concepts

BioproductsAbiotic componentBiotic componentEnvironmental scienceEcologyBiologyBiofuelMicrobial Metabolic Engineering and BioproductionProcess Optimization and IntegrationBiofuel production and bioconversion