Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary
Anne‐Amandine Chassot, Morgane Le Rolle, Geneviève Jolivet, Isabelle Stévant, Jean‐Marie Guigonis, Fabio Da Silva, Serge Nef, Éric Pailhoux, Andreas Schedl, Norbert B. Ghyselinck, Marie‐Christine Chaboissier
Abstract
expression is independent of ATRA production by ALDH1A proteins and that germ cells progress through meiosis. Together, these data demonstrate that ATRA signaling is dispensable for instructing meiosis initiation in female germ cells.
Topics & Concepts
Retinoic acidBiologyMeiosisTretinoinOvaryCell biologyOocyteRetinoic acid-inducible orphan G protein-coupled receptorRetinoic acid receptorGeneGeneticsEmbryoGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesReproductive Biology and FertilityGenomics and Chromatin Dynamics