Catalytic Enantioselective Isocyanide‐Based Reactions: Beyond Passerini and Ugi Multicomponent Reactions
Jian Luo, Guo‐Shu Chen, Shu‐Jie Chen, Zhaodong Li, Yun‐Lin Liu
Abstract
The development of catalytic enantioselective isocyanide-based reactions is currently of great interest because the resulting products are valuable in organic synthesis, pharmacological chemistry, and materials science. This review assembles and comprehensively summarizes the recent achievements in this rapidly growing area according to the reaction types. Special attention is paid to the advantages, limitations, possible mechanisms, and synthetic applications of each reaction. In addition, a personal outlook on the opportunities for further exploration is given at the end.
Topics & Concepts
Enantioselective synthesisIsocyanideUgi reactionCatalysisCombinatorial chemistryOrganic synthesisChemistryNanotechnologyBiochemical engineeringOrganic chemistryMaterials scienceEngineeringMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of heterocyclic compounds