Recent advances in iodine–DMSO mediated C(sp<sup>3</sup>)–H functionalization of methyl-azaarenes <i>via</i> Kornblum oxidation
Swadhin Swaraj Acharya, Sagarika Patra, Liza Mama Barad, Ananya Roul, Bibhuti Bhusan Parida
Abstract
In the iodine–DMSO medium, the methyl group of methyl azaarenes is converted into aldehyde via Kornblum oxidation and trapped in situ by nucleophiles to create azaarene-linked functionalized scaffolds.
Topics & Concepts
ChemistryIodineMoleculeOrganic chemistryMedicinal chemistryCombinatorial chemistryCatalytic C–H Functionalization Methods