Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity
Jianan Li, Huilan Liu, Qile Guo, Yiying Zhang, Jiaxin Li, Tian Diao, Liangtao Zheng, Zenghua Deng, YU Yang, Xueyan Chen, Shishang Qin, Jinhu Li, Yao He, Wanzhuo He, Dongfang Liu, Yufei Bo, Chang Liu, Huinan Lu, Hongtao Fan, Xueda Hu, Jirun Peng, Linnan Zhu, Jianzhong Jeff Xi, Dongfang Wang, Zemin Zhang
Topics & Concepts
BiologyMyofibroblastPopulationImmune checkpointPhenotypeImmunityImmune systemCRISPRCancer researchRNA interferenceCell biologyMediatorImmunologyComputational biologyImmunotherapyInterferonFibroblastSignal transductionNeurosciencePhenotypic screeningGenomicsBystander effectSuppressorStromal cellRegulatorEpigeneticsFunctional genomicsDiseaseImmunosurveillanceClinical trialBioinformaticsSignallingCancer Immunotherapy and BiomarkersCancer Cells and MetastasisHER2/EGFR in Cancer Research