Caerin 1 Peptides, the Potential Jack‐of‐All‐Trades for the Multiple Antibiotic‐Resistant Bacterial Infection Treatment and Cancer Immunotherapy
Liyin Xiao, Xiaodan Yang, Junjie Li, Pingping Zhang, Shuxian Tang, Dongming Cao, Shu Chen, Hejie Li, Wei Zhang, Guoqiang Chen, Guoying Ni, Tianfang Wang, Xiaosong Liu
Abstract
century. A number of naturally derived antimicrobial peptides possess multiple functions in host defense, including anti-infective and anticancer activities. One of which is known as the caerin 1 family peptides. The microbicidal properties of these peptides have been long discussed. The recent studies also established the usage of two members in this family, caerin 1.1 and caerin 1.9, in antimultiple antibiotic-resistant bacteria species. It is increasingly evident that caerin 1.1 and caerin 1.9 also contain additional activities in the suppression of tumor. In this review, we briefly outline the therapeutic potentials and possible mechanism of action of caerin 1.1 and 1.9 in the treatment of multiple antibiotic-resistant bacterial infection and cancer immunotherapy.