Synthesis of novel fatty acid 3,4-dihydropyrimidin-2-(1<i>H</i>)-one and antitumoral activity against breast and gastric cancer cells
Elise Ane Maluf Rios, Camila M. Dea, E. R. F. B. dos Santos, Marcelo G. Montes D’Oca, Daniel S. Rampon, Fabiane M. Nachtigall, Leonardo S. Santos, Luís Guzmán, Rodrigo Moore‐Carrasco, Danitza Rebolledo-Mira, Caroline Da Ros Montes D’Oca
Abstract
Monastrol is a cell-permeable molecule recognized as an inhibitor of mitotic kinesin Eg5, that is over-expressed in tumor cells and is a very promising target for developing new drugs for cancer disease.
Topics & Concepts
CancerChemistryKinesinCancer researchCancer cellMitosisBreast cancerCellPharmacologyBiochemistryCell biologyBiologyMedicineInternal medicineMicrotubuleSynthesis and biological activityMulticomponent Synthesis of HeterocyclesCancer Mechanisms and Therapy