Lymphomas with kidney involvement: the French multicenter retrospective LyKID study
Milena Kohn, Alexandre Karras, Mohamad Zaidan, Charles Bénière, Jean-Baptiste de Fréminville, Kamel Laribi, Marie Claire Perrin, Marion Malphettes, Ronan Le Calloch, Bruno Anglaret, Juliana Martiniuc, Sarah Bailly, Sylvie Chevret, Thierry Jo Molina, Éric Thervet, Catherine Thiéblemont
Abstract
The LyKID study is a nationwide survey in France of lymphoma patients with renal involvement based on biopsy and/or imaging, to evaluate its impact on disease outcome and renal function. A total of 87 adult cases of B or T-cell lymphomas were retrospectively analyzed. Interstitial topography was observed in most of the kidney biopsies (54/66; 80%). Kidney failure (glomerular filtration rate <60 mL/min/1.73 m2) was present in 47% of patients and was associated with non-significantly different outcome. After lymphoma treatment, 44% of patients had persistent chronic kidney failure (CKF); kidney failure at diagnosis was the only parameter associated with CKF in multivariate analysis. DLBCL (diffuse large B-cell lymphomas) represented half of the series, with noticeably CNS (central neurological system) relapse in 17% patients, while fewer than one of two patients had received CNS prophylaxis. To our knowledge, the LyKID study represents the largest published non-autopsy lymphoma series with renal involvement.