Tirzepatide-Associated Colonic Ischemia
David Bayless, Jasraj Singh, Byoung Uk Park, Seth Sweetser
Abstract
The use of the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist tirzepatide has markedly increased for the treatment of weight loss and management of diabetes mellitus. Gastrointestinal adverse effects of GLP-1/GIP agonist therapy, including nausea, vomiting, and constipation, are common. We report a case of colonic ischemia in a 62-year-old woman which developed in association with the use of tirzepatide for weight loss. This report highlights a potential risk relationship between GLP-1/GIP agonist therapy and colonic ischemia and identifies risk factors that should be considered before prescribing tirzepatide.
Topics & Concepts
MedicineAgonistConstipationNauseaVomitingWeight lossInternal medicineGlucagon-like peptide-1Glucagon-like peptide 1 receptorDiabetes mellitusIschemiaGastroenterologyAdverse effectEndocrinologyReceptorType 2 diabetesObesityPotassium and Related DisordersDiabetes Treatment and ManagementGastroesophageal reflux and treatments