Novel Mannich bases with strong carbonic anhydrases and acetylcholinesterase inhibition effects: 3-(aminomethyl)-6-{3-[4-(trifluoromethyl)phenyl]acryloyl}-2(3H)- benzoxazolones
Sinan Bilginer, Barış Anıl, Mehmet Koca, Yeliz Demir, İlhami Gülçın
Abstract
(in terms of hCA I, hCA II, and AChE inhibition effects, respectively) to determine the binding profiles of the series with these enzymes. Additionally, the prediction of ADME profiles of the compounds pointed out that the newly synthesized compounds had desirable physicochemical properties as lead compounds for further studies.
Topics & Concepts
ChemistryADMECarbonic anhydraseAcetylcholinesteraseTrifluoromethylTacrineAchéStereochemistryAcetazolamideEnzymeCarbonic anhydrase IIDocking (animal)Organic chemistryBiochemistryIn vitroAlkylMedicineNursingAnesthesiaEnzyme function and inhibitionSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and Activities