Design, synthesis and chemoinformatic studies of new thiazolopyrimidine derivatives as potent anticancer agents via phosphodiesterase-5 inhibition and apoptotic inducing activity
Mohamed T. M. Nemr, Mohamed A. Mohamed Teleb, Asmaa M. AboulMagd, Mostafa E. El-Naggar, Noha Gouda, Asmaa Abdel-Ghany, Yaseen A. M. M. Elshaier
Topics & Concepts
ChemistryApoptosisIC50Cytotoxic T cellSildenafilPhosphodiesteraseCancer cellCell culturecGMP-specific phosphodiesterase type 5CancerDocking (animal)PharmacologyCancer researchIn vitroEnzymeBiochemistryInternal medicineBiologyNursingMedicineGeneticsPhosphodiesterase function and regulationMast cells and histaminePhenothiazines and Benzothiazines Synthesis and Activities