Myonuclear addition is associated with sex-specific fiber hypertrophy and occurs in relation to fiber perimeter not cross-sectional area
Lukas Moesgaard, Søren Jessen, Abigail L. Mackey, Morten Hostrup
Abstract
Here, we show that resistance training-induced hypertrophy of type I fibers is greater in males than females. Myonuclear addition was strongly associated with fiber hypertrophy but did not differ between sexes in type I fibers. Furthermore, whereas muscle hypertrophy was accompanied by an increase in myonuclear domain, fiber perimeter per myonucleus remained constant. Thus, myonuclear addition occurs in relation to fiber perimeter during muscle hypertrophy but does not explain sex-specific hypertrophy of type I fibers.
Topics & Concepts
Muscle hypertrophyPerimeterFiberInternal medicineEndocrinologyAnatomyBiologyMedicineChemistryMathematicsGeometryOrganic chemistryMuscle Physiology and DisordersMuscle activation and electromyography studiesChildren's Physical and Motor Development