All DACs in a Row: Domain Architectures of Bacterial and Archaeal Diadenylate Cyclases
Michael Y. Galperin
Abstract
Cyclic dimeric AMP (c-di-AMP) is a widespread second messenger that controls such key functions as osmotic homeostasis, peptidoglycan biosynthesis, and response to various stresses. C-di-AMP is synthesized by diadenylate cyclases that contain the DAC (DisA_N) domain, which was originally characterized as the N-terminal domain in the DNA integrity scanning protein DisA. In other experimentally studied diadenylate cyclases, DAC domain is typically located at the protein C termini and its enzymatic activity is controlled by one or more N-terminal domains.
Topics & Concepts
BiologyGeneBiochemistryPeptidoglycanProtein domainSignal transductionArchitecture domainCell biologyComputational biologyVisual artsEnterprise architecture managementArchitectureEnterprise architectureArtBacterial Genetics and BiotechnologyVibrio bacteria research studiesBacterial biofilms and quorum sensing