Extracellular vesicles secreted by primary human bronchial epithelial cells reduce <i>Pseudomonas aeruginosa</i> burden and inflammation in cystic fibrosis mouse lung
Sharanya Sarkar, Roxanna Barnaby, Amanda Nymon, Douglas J. Taatjes, Thomas J. Kelley, Bruce A. Stanton
2023American Journal of Physiology-Lung Cellular and Molecular Physiology10 citationsDOIOpen Access PDF
Abstract
Our findings show that extracellular vesicles secreted by primary human bronchial epithelial cells significantly reduce Pseudomonas aeruginosa burden, inflammation, and weight loss in a cystic fibrosis mouse model of infection.
Topics & Concepts
Cystic fibrosisPseudomonas aeruginosaInflammationExtracellularExtracellular vesiclesLungMicrobiologyFibrosisEpitheliumBiologyPathologyImmunologyBacteriaMedicineCell biologyInternal medicineGeneticsExtracellular vesicles in diseaseBacterial Infections and VaccinesNeonatal Respiratory Health Research